{"id":3944,"date":"2020-02-24T00:27:11","date_gmt":"2020-02-24T00:27:11","guid":{"rendered":"https:\/\/www.animalhealthfoundation.net\/blog\/?p=3944"},"modified":"2020-02-24T00:37:13","modified_gmt":"2020-02-24T00:37:13","slug":"innovative-therapy-puts-blaine-wa-dogs-cancer-into-remission","status":"publish","type":"post","link":"https:\/\/www.animalhealthfoundation.org\/blog\/2020\/02\/innovative-therapy-puts-blaine-wa-dogs-cancer-into-remission\/","title":{"rendered":"Innovative therapy puts Blaine, WA dog\u2019s cancer into remission"},"content":{"rendered":"
The Northern Light Community Newspaper, Bellingham, WA<\/h5>\n
\"Blaine<\/a><\/h5>\n
Blaine dog Wiley with his veterinary team at Bellingham, WA Veterinary. From l., Brittany Grant, Sebastian Grant, Dr. Kevin Steele, Sharon Pozzi and Dr. Edmund Sullivan.<\/h6>\n
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PHOTO COURTESY OF DR. KEVIN STEELE<\/div>\n<\/div>\n<\/div>\n<\/div>\n
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  • by Jami Makan<\/li>\n<\/ul>\n<\/div>\n
    \n

    When Jackie Craig got her dog Wiley from a ranch when he was eight weeks old, she expected him to have a long, healthy life. That\u2019s because he\u2019s a Blue Heeler, a type of Australian Cattle Dog known for its long, healthy lifespan and lack of predisposed conditions. Wiley quickly became a beloved figure at The Hair Shop on Martin Street in Blaine where Craig works. \u201cHe\u2019s the barbershop dog,\u201d she said. \u201cEverybody knows him.\u201d<\/p>\n

    So it came as a shock when Wiley, at the age of seven and a half, was diagnosed with lymphoma in August last year. Craig first noticed that Wiley was gaining weight and would start coughing when he drank. She took him in for an appointment at Bellingham Veterinary, where Dr. Edmund Sullivan performed blood work and diagnosed Wiley with B-cell lymphoma, a type of blood cancer. It is also known in people as non-Hodgkin\u2019s lymphoma. \u201cIt turns out the lymph nodes in his neck were extremely enlarged,\u201d Craig said. \u201cHe was in very sorry shape, and they said he would\u2019ve died within two weeks.\u201d<\/p>\n

    Although she didn\u2019t have pet insurance \u2013 \u201cMy biggest mistake,\u201d Craig said \u2013 she decided to pay for chemotherapy for Wiley. \u201cI did not think he was going to make it,\u201d she said. \u201cI just wanted to prolong his life. It was agonizing trying to decide whether to put my dog to sleep.\u201d<\/p>\n

    At first, Dr. Sullivan performed chemotherapy on Wiley once a week. Unfortunately, it wasn\u2019t working well. \u201cWiley had a very poor response to standard chemotherapy,\u201d said Dr. Sullivan. \u201cOn the standard therapy, he didn\u2019t get into any kind of remission at all. He quickly would relapse.\u201d<\/span><\/p>\n

    That\u2019s when Dr. Sullivan decided to try a new approach being developed around the country. Through a separate Bellingham company named Aurelius Biotherapeutics, of which his wife Dr. Theresa Westfall is the CEO, Dr. Sullivan has been working for years in conjunction with the Fred Hutchinson Cancer Research Center in Seattle, as an off-campus research partner. \u201cWe have developed therapies for dogs as patients through that relationship,\u201d said Dr. Sullivan. One of those therapies is known as adoptive T-cell therapy. It is a therapy that is also used on some human patients, and Dr. Sullivan decided to try it on Wiley.<\/span><\/p>\n

    \u201cBasically, it is a method where we first take blood out of the dog,\u201d explained Dr. Kevin Steele, Dr. Sullivan\u2019s Blaine-based lab researcher. \u201cWe take anti-tumor T-cells away from the influence of the tumor. The T-cells, the anti-cancer cells, they are in culture now. We give them dead tumor to attack. They expand and get very anti-tumor. All of this is happening in culture. Then we inject them back into the dog.\u201d<\/p>\n

    Dr. Steele said that adoptive T-cell therapy is typically used in conjunction with standard chemotherapy. First, the chemotherapy kills off rapidly dividing tumor cells, and then the T-cells, after being \u201cjazzed up\u201d in the laboratory, are injected to \u201chunt down\u201d any surviving cancer cells. The first time Dr. Steele and Dr. Sullivan tried the technique was in 2016, and since then, they have treated about a hundred dogs together. They have conditional USDA approval to provide the treatment, and they are currently working on overcoming additional levels of regulatory hurdles to expand their facility.<\/p>\n

    \u201cWith standard therapy, we don\u2019t have any cures,\u201d said Dr. Sullivan. \u201cSo none of them survive. This immunotherapy, meanwhile, has resulted in a fair percentage of dogs living for long periods of time, and some of them being cured,\u201d which he defines as being cancer-free for longer than two years after a diagnosis. Some dogs he has treated have gone as long as four and a half years (and counting) without relapsing. \u201cWe believe there\u2019s something to this.\u201d<\/p>\n

    The experimental treatment was performed at no cost to Craig. The doctors grew T-cells for Wiley and then gave him an additional dose of standard therapy followed by two infusions of the T-cells. Wiley went into remission and has gone without additional chemotherapy for several months now. \u201cJust last week, we did an analysis and he was free of disease \u2013 there was no detectable disease,\u201d said Dr. Sullivan. \u201cWe will generate another batch of T-cells for him to see if we can extend his remission even longer. There\u2019s a chance he may be cured \u2013 we don\u2019t know that until he\u2019s gone two years since his diagnosis \u2013 but we\u2019re already six months in. We\u2019re a quarter of the way there.\u201d<\/span><\/p>\n

    During the entire process, Craig said that Wiley\u2019s suffering was minimal, and that he didn\u2019t lose hair. \u201cNow he\u2019s got the puppy bounce,\u201d said Craig. \u201cHe was pretty sick when he was going through chemo. I could only get him to eat steak. Now he\u2019s eating completely normal and he\u2019s right back to his old self, playing with other dogs.\u201d<\/p>\n

    Craig is extremely grateful to Dr. Steele and Dr. Sullivan, who will continue to monitor Wiley\u2019s condition. \u201cKevin is an angel,\u201d she said. \u201cAnd Dr. Sullivan, he sits on the floor and talks to the animals. He loves the animals. His entire staff is just very compassionate.\u201d<\/span><\/p>\n

    Craig said that with so many dogs getting cancer, these treatments have come a long way and are worth it. \u201cIt gives other people with dogs hope,\u201d she said.<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

    The Northern Light Community Newspaper, Bellingham, WA Blaine dog Wiley with his veterinary team at Bellingham, WA Veterinary. From l., Brittany Grant, Sebastian Grant, Dr. Kevin Steele, Sharon Pozzi and Dr. Edmund Sullivan. PHOTO COURTESY OF DR. KEVIN STEELE by Jami Makan When Jackie Craig got her dog Wiley from a ranch when he was […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[12,17],"tags":[],"class_list":["post-3944","post","type-post","status-publish","format-standard","hentry","category-dogs","category-medical-issues"],"yoast_head":"\nInnovative therapy puts Blaine, WA dog\u2019s cancer into remission | The Animal Health Foundation<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.animalhealthfoundation.org\/blog\/2020\/02\/innovative-therapy-puts-blaine-wa-dogs-cancer-into-remission\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Innovative therapy puts Blaine, WA dog\u2019s cancer into remission | The Animal Health Foundation\" \/>\n<meta property=\"og:description\" content=\"The Northern Light Community Newspaper, Bellingham, WA Blaine dog Wiley with his veterinary team at Bellingham, WA Veterinary. 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