{"id":4053,"date":"2020-10-15T21:08:39","date_gmt":"2020-10-15T21:08:39","guid":{"rendered":"https:\/\/www.animalhealthfoundation.net\/blog\/?p=4053"},"modified":"2020-10-15T21:08:39","modified_gmt":"2020-10-15T21:08:39","slug":"study-upends-understanding-about-joint-injuries","status":"publish","type":"post","link":"https:\/\/www.animalhealthfoundation.org\/blog\/2020\/10\/study-upends-understanding-about-joint-injuries\/","title":{"rendered":"Study upends understanding about joint injuries"},"content":{"rendered":"
\n

From the Cornell University “Chronicle”<\/h1>\n

By\u00a0Melanie Greaver Cordova<\/a>\u00a0|<\/h2>\n

\n
<\/div>\n<\/div>\n
\n
\n

An injury to the anterior cruciate ligament (ACL) can lead to severe osteoarthritis in both animal and human patients. Now, a new interdisciplinary study on the protein that lubricates our joints says that lubricant\u00a0may actually be a precursor of joint disease.<\/p>\n

The paper,\u00a0published Oct. 7 in Scientific Reports<\/a>, is the first that investigates the role of a protein, known as lubricin, in ACL-type injuries in dogs. It may also have larger implications for similar injuries in humans as well as the potential for treatments and therapeutics.<\/p>\n

\u201cLubricin is crucial for normal joint function and the lubrication of cartilage,\u201d said\u00a0Heidi Reesink<\/a>, Ph.D. \u201916, the Harry M. Zweig Assistant Professor in Equine Health at the College of Veterinary Medicine (CVM) and senior author on the paper. \u201cWe know that if a person or animal doesn\u2019t make that protein, they will develop devastating joint disease affecting all the major weight-bearing joints.\u201d<\/p>\n

Lubricin is universal to mammals, including humans, though there is conflicting data regarding its role in joint injuries. Reesink\u2019s study found that, in canine patients that had suffered a ligament tear in the knee, lubricin increased within the joint \u2013 the opposite of conventional assumptions in medicine. \u201cThe dogma in this field has been that lubricin decreases in joint disease,\u201d Reesink said.<\/p>\n

In three canine patients that had a joint injury, lubricin dramatically increased in the time between their initial injury but before any signs of arthritis in their X-rays.<\/p>\n

\u201cThis indicates that the presence of increased lubricin might actually be a biomarker for predicting future osteoarthritis,\u201d said Reesink. \u201cWe also saw increased lubricin in dogs months to years after they injured their ACLs, suggesting that lubricin might be an indicator of ongoing joint instability.\u201d<\/p>\n

Reesink said increased lubricin could consequently be a signal for clinicians to intervene or try a different treatment approach.<\/p>\n

Reesink and her collaborators laid the groundwork for this new study by completing a systematic review of the literature surrounding lubricin in both human and veterinary medicine.\u00a0The review<\/a>\u00a0waspublished this summer in the journal Osteoarthritis and Cartilage.<\/p>\n

The overall finding of the review: There is no unified consensus on how lubricin is altered in other domestic veterinary species and in human joint injury, demonstrating the need for further study \u2013 which Reesink\u2019s new paper has done.<\/p>\n

\u201cIn looking at horses and dogs, we\u2019re seeing the same pattern,\u201d she said. \u201cThe strongest piece of data would be to show it in humans as well.\u201d<\/p>\n

Reesink and her collaborators worked with the Cornell Veterinary Biobank to obtain samples. The biobank supports CVM researchers as well as scientists across the globe, using biological samples collected from both ill and healthy animals at the Cornell University Hospital for Animals (CUHA). The samples are processed, catalogued and provided to researchers, which accelerates biomedical research.<\/p>\n

Among the motivators for this study, said Reesink, is that a large number of cases in the small animal orthopedic section at CUHA is knee ligament injury, which is common in dogs.<\/p>\n

\u201cWe can help both animals and humans by potentially coming up with better diagnostics, by more fully understanding how these molecules work and designing therapies beneficial to both, by taking advantage of these naturally occurring cases and improving orthopedic care,\u201d Reesink said.<\/p>\n

In the veterinary realm, Reesink\u2019s team plans to do a follow-up longitudinal study in dogs, examining multiple time points in a patient\u2019s injury, treatment and recovery process. They also hope to draw similar connections in human ACL and other orthopedic injuries.<\/p>\n

Currently, Reesink is examining parallel samples from both the Cornell Veterinary Biobank and the Hospital for Special Surgery, using funding from a pilot grant from the\u00a0Weill Cornell Medicine Clinical and Translational Science Center<\/a>.<\/p>\n

CVM authors on the paper include Dr. Bethany Cummings, assistant professor in the Department of Biomedical Sciences; professors and small animal surgeons Dr. Kei Hayashi, Dr. Ursula Krotscheck and Rory Todhunter, Ph.D. \u201992; and Dr. Philippa Johnson, assistant professor in the section of diagnostic imaging. Co-lead authors are David Gludish, a combined D.V.M. and Ph.D. student, and Yuyan Wang, a doctoral student in the College of Engineering.<\/p>\n

Melanie Greaver Cordova is managing editor at the College of Veterinary Medicine.<\/em><\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

From the Cornell University “Chronicle” By\u00a0Melanie Greaver Cordova\u00a0| October 13, 2020 An injury to the anterior cruciate ligament (ACL) can lead to severe osteoarthritis in both animal and human patients. Now, a new interdisciplinary study on the protein that lubricates our joints says that lubricant\u00a0may actually be a precursor of joint disease. The paper,\u00a0published Oct. […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-4053","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"\nStudy upends understanding about joint injuries | The Animal Health Foundation<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.animalhealthfoundation.org\/blog\/2020\/10\/study-upends-understanding-about-joint-injuries\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Study upends understanding about joint injuries | The Animal Health Foundation\" \/>\n<meta property=\"og:description\" content=\"From the Cornell University “Chronicle” By\u00a0Melanie Greaver Cordova\u00a0| October 13, 2020 An injury to the anterior cruciate ligament (ACL) can lead to severe osteoarthritis in both animal and human patients. Now, a new interdisciplinary study on the protein that lubricates our joints says that lubricant\u00a0may actually be a precursor of joint disease. The paper,\u00a0published Oct. […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.animalhealthfoundation.org\/blog\/2020\/10\/study-upends-understanding-about-joint-injuries\/\" \/>\n<meta property=\"og:site_name\" content=\"The Animal Health Foundation\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/animalhealthfoundation\/\" \/>\n<meta property=\"article:published_time\" content=\"2020-10-15T21:08:39+00:00\" \/>\n<meta name=\"author\" content=\"The Animal Health Foundation\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"The Animal Health Foundation\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.animalhealthfoundation.org\/blog\/2020\/10\/study-upends-understanding-about-joint-injuries\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.animalhealthfoundation.org\/blog\/2020\/10\/study-upends-understanding-about-joint-injuries\/\"},\"author\":{\"name\":\"The Animal Health Foundation\",\"@id\":\"https:\/\/www.animalhealthfoundation.org\/blog\/#\/schema\/person\/f475447cd5f132c17522d9188f6fcb9b\"},\"headline\":\"Study upends understanding about joint injuries\",\"datePublished\":\"2020-10-15T21:08:39+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.animalhealthfoundation.org\/blog\/2020\/10\/study-upends-understanding-about-joint-injuries\/\"},\"wordCount\":715,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/www.animalhealthfoundation.org\/blog\/#organization\"},\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.animalhealthfoundation.org\/blog\/2020\/10\/study-upends-understanding-about-joint-injuries\/\",\"url\":\"https:\/\/www.animalhealthfoundation.org\/blog\/2020\/10\/study-upends-understanding-about-joint-injuries\/\",\"name\":\"Study upends understanding about joint injuries | The Animal Health Foundation\",\"isPartOf\":{\"@id\":\"https:\/\/www.animalhealthfoundation.org\/blog\/#website\"},\"datePublished\":\"2020-10-15T21:08:39+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/www.animalhealthfoundation.org\/blog\/2020\/10\/study-upends-understanding-about-joint-injuries\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.animalhealthfoundation.org\/blog\/2020\/10\/study-upends-understanding-about-joint-injuries\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.animalhealthfoundation.org\/blog\/2020\/10\/study-upends-understanding-about-joint-injuries\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.animalhealthfoundation.org\/blog\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Study upends understanding about joint injuries\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.animalhealthfoundation.org\/blog\/#website\",\"url\":\"https:\/\/www.animalhealthfoundation.org\/blog\/\",\"name\":\"The Animal Health Foundation\",\"description\":\"Our Blog\",\"publisher\":{\"@id\":\"https:\/\/www.animalhealthfoundation.org\/blog\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.animalhealthfoundation.org\/blog\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.animalhealthfoundation.org\/blog\/#organization\",\"name\":\"Animal Health Foundation of California\",\"url\":\"https:\/\/www.animalhealthfoundation.org\/blog\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.animalhealthfoundation.org\/blog\/#\/schema\/logo\/image\/\",\"url\":\"\",\"contentUrl\":\"\",\"caption\":\"Animal Health Foundation of California\"},\"image\":{\"@id\":\"https:\/\/www.animalhealthfoundation.org\/blog\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/www.facebook.com\/animalhealthfoundation\/\"]},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.animalhealthfoundation.org\/blog\/#\/schema\/person\/f475447cd5f132c17522d9188f6fcb9b\",\"name\":\"The Animal Health Foundation\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/secure.gravatar.com\/avatar\/35d2d92234619be7650525ff812317b3c1c8e3d00c51a1bc0e49e7f5ac684f2d?s=96&d=mm&r=g\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/35d2d92234619be7650525ff812317b3c1c8e3d00c51a1bc0e49e7f5ac684f2d?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/35d2d92234619be7650525ff812317b3c1c8e3d00c51a1bc0e49e7f5ac684f2d?s=96&d=mm&r=g\",\"caption\":\"The Animal Health Foundation\"},\"sameAs\":[\"http:\/\/www.animalhealthfoundation.org\"],\"url\":\"https:\/\/www.animalhealthfoundation.org\/blog\/author\/ahfadmin\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Study upends understanding about joint injuries | The Animal Health Foundation","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.animalhealthfoundation.org\/blog\/2020\/10\/study-upends-understanding-about-joint-injuries\/","og_locale":"en_US","og_type":"article","og_title":"Study upends understanding about joint injuries | The Animal Health Foundation","og_description":"From the Cornell University “Chronicle” By\u00a0Melanie Greaver Cordova\u00a0| October 13, 2020 An injury to the anterior cruciate ligament (ACL) can lead to severe osteoarthritis in both animal and human patients. Now, a new interdisciplinary study on the protein that lubricates our joints says that lubricant\u00a0may actually be a precursor of joint disease. The paper,\u00a0published Oct. […]","og_url":"https:\/\/www.animalhealthfoundation.org\/blog\/2020\/10\/study-upends-understanding-about-joint-injuries\/","og_site_name":"The Animal Health Foundation","article_publisher":"https:\/\/www.facebook.com\/animalhealthfoundation\/","article_published_time":"2020-10-15T21:08:39+00:00","author":"The Animal Health Foundation","twitter_card":"summary_large_image","twitter_misc":{"Written by":"The Animal Health Foundation","Est. reading time":"4 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.animalhealthfoundation.org\/blog\/2020\/10\/study-upends-understanding-about-joint-injuries\/#article","isPartOf":{"@id":"https:\/\/www.animalhealthfoundation.org\/blog\/2020\/10\/study-upends-understanding-about-joint-injuries\/"},"author":{"name":"The Animal Health Foundation","@id":"https:\/\/www.animalhealthfoundation.org\/blog\/#\/schema\/person\/f475447cd5f132c17522d9188f6fcb9b"},"headline":"Study upends understanding about joint injuries","datePublished":"2020-10-15T21:08:39+00:00","mainEntityOfPage":{"@id":"https:\/\/www.animalhealthfoundation.org\/blog\/2020\/10\/study-upends-understanding-about-joint-injuries\/"},"wordCount":715,"commentCount":0,"publisher":{"@id":"https:\/\/www.animalhealthfoundation.org\/blog\/#organization"},"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.animalhealthfoundation.org\/blog\/2020\/10\/study-upends-understanding-about-joint-injuries\/","url":"https:\/\/www.animalhealthfoundation.org\/blog\/2020\/10\/study-upends-understanding-about-joint-injuries\/","name":"Study upends understanding about joint injuries | The Animal Health Foundation","isPartOf":{"@id":"https:\/\/www.animalhealthfoundation.org\/blog\/#website"},"datePublished":"2020-10-15T21:08:39+00:00","breadcrumb":{"@id":"https:\/\/www.animalhealthfoundation.org\/blog\/2020\/10\/study-upends-understanding-about-joint-injuries\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.animalhealthfoundation.org\/blog\/2020\/10\/study-upends-understanding-about-joint-injuries\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.animalhealthfoundation.org\/blog\/2020\/10\/study-upends-understanding-about-joint-injuries\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.animalhealthfoundation.org\/blog\/"},{"@type":"ListItem","position":2,"name":"Study upends understanding about joint injuries"}]},{"@type":"WebSite","@id":"https:\/\/www.animalhealthfoundation.org\/blog\/#website","url":"https:\/\/www.animalhealthfoundation.org\/blog\/","name":"The Animal Health Foundation","description":"Our Blog","publisher":{"@id":"https:\/\/www.animalhealthfoundation.org\/blog\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.animalhealthfoundation.org\/blog\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.animalhealthfoundation.org\/blog\/#organization","name":"Animal Health Foundation of California","url":"https:\/\/www.animalhealthfoundation.org\/blog\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.animalhealthfoundation.org\/blog\/#\/schema\/logo\/image\/","url":"","contentUrl":"","caption":"Animal Health Foundation of California"},"image":{"@id":"https:\/\/www.animalhealthfoundation.org\/blog\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/animalhealthfoundation\/"]},{"@type":"Person","@id":"https:\/\/www.animalhealthfoundation.org\/blog\/#\/schema\/person\/f475447cd5f132c17522d9188f6fcb9b","name":"The Animal Health Foundation","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/secure.gravatar.com\/avatar\/35d2d92234619be7650525ff812317b3c1c8e3d00c51a1bc0e49e7f5ac684f2d?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/35d2d92234619be7650525ff812317b3c1c8e3d00c51a1bc0e49e7f5ac684f2d?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/35d2d92234619be7650525ff812317b3c1c8e3d00c51a1bc0e49e7f5ac684f2d?s=96&d=mm&r=g","caption":"The Animal Health Foundation"},"sameAs":["http:\/\/www.animalhealthfoundation.org"],"url":"https:\/\/www.animalhealthfoundation.org\/blog\/author\/ahfadmin\/"}]}},"_links":{"self":[{"href":"https:\/\/www.animalhealthfoundation.org\/blog\/wp-json\/wp\/v2\/posts\/4053","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.animalhealthfoundation.org\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.animalhealthfoundation.org\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.animalhealthfoundation.org\/blog\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.animalhealthfoundation.org\/blog\/wp-json\/wp\/v2\/comments?post=4053"}],"version-history":[{"count":1,"href":"https:\/\/www.animalhealthfoundation.org\/blog\/wp-json\/wp\/v2\/posts\/4053\/revisions"}],"predecessor-version":[{"id":4054,"href":"https:\/\/www.animalhealthfoundation.org\/blog\/wp-json\/wp\/v2\/posts\/4053\/revisions\/4054"}],"wp:attachment":[{"href":"https:\/\/www.animalhealthfoundation.org\/blog\/wp-json\/wp\/v2\/media?parent=4053"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.animalhealthfoundation.org\/blog\/wp-json\/wp\/v2\/categories?post=4053"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.animalhealthfoundation.org\/blog\/wp-json\/wp\/v2\/tags?post=4053"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}