Baseball team’s special canine bat boy dies of lymphoma
Chase the golden retriever entertained fans of the Trenton Thunder, a New York Yankees affiliate in New Jersey, for years before his death from lymphoma on Monday. The team and fans threw Chase a retirement and birthday party last week, and last month he was honored at Yankee Stadium. Chase is succeeded by one of his offspring, Derby, who’ll carry on the family tradition of retrieving bats, carrying water bottles to umpires and catching discs in the outfield. The team posted a tribute to Chase on its website.
TRENTON, N.J. (AP) — He doggedly did his work, this pinstriped pooch who faithfully served minor leaguers of the New York Yankees while providing big league entertainment.
Chase, the bat-retrieving golden retriever for the Double-A Trenton Thunder who made highlight reels all across baseball for a decade, has died at 13.
“Chase was there a long time. He put a lot of smiles on people’s faces,” Yankees pitcher Joba Chamberlain, who played in Trenton, said Tuesday night.
“You know it’s going to be sad, but his lineage is carried on. You know it’s something that people are going to miss, but it was fun to be around Chase,” he said.
Chase lived just long enough to be thrown a retirement party by the Thunder last Friday night — featuring Chase bobbleheads, no less. The team said he died Monday.
Chase had been diagnosed in February with a form of lymphoma and had arthritis.
The Thunder’s website Tuesday featured a photo of their late mascot with a bat in his mouth and the caption, “In Loving Memory, Chase That Golden Thunder.”
His bat-retrieving legacy will live on with his son Derby, who continues to be part of the Thunder’s home game entertainment. Another son, Ollie, performs with the New Hampshire Fisher Cats.
Chase made his debut with the Thunder in 2002. He would trot out in the bottom of the first inning to the batter’s box to pick up bats with his mouth and bring them back to the dugout. He also carried a woven basket with bottles of chilled water to the umpires and entertained fans by running down flying discs in the outfield.
At Friday’s celebration, which coincided with his birthday party, fans were encouraged to bring their dogs to the game.
Last month, he was also honored on the field at Yankee Stadium. Chamberlain petted Chase before the game and infielder David Adams came over to greet his old friend.
Adams recalled Chase retrieving his bat, doing it without leaving teeth marks in the wood.
“He’s not chomping at the bit,” Adams said then. “Or at the bat, either.”
Dogs of all shapes and sizes were at Trenton’s game Friday night against Reading, sitting in the stands with their owners. As fans filed in, Chase lounged on the grass outside the Thunder’s dugout on the first-base side.
A tribute to Chase’s career was shown on the video board. Chase was in position near the bench when Eduardo Nunez — who has since rejoined the Yankees — led off for Trenton in the bottom of the first inning. After the at-bat, Chase trotted out, picked up Nunez’s bat and returned to the dugout to a big cheer from the crowd.
Research reveals dogs of the Americas
Inuit sled dogs and other Alaskan breeds are the only dogs with American origins, according to new research. Although the original canine stock has been traced to Asia, there is evidence of dogs in the Americas dating to 10,000 years ago, before transoceanic travel brought Europeans and their dogs to the continent. “Nobody knows exactly what happened,” researcher Peter Savolainen said. “Most probably migrated together with the humans that entered America from Asia via the Bering Strait. These humans became today’s Indians and Inuits.” The canines became Inuit sled dogs, the Greenland dog and the Eskimo dog, according to the research.
Alaskan breeds — such as Inuit sled dogs, the Eskimo dog and the Greenland dog — are the only canines with actual American roots, according to DNA analysis. All of these pooches hail from the 49th state and nearby areas, according to the study, published in the latest Proceedings of the Royal Society B.
“They are all equally American,” co-author Peter Savolainen told Discovery News. “They originate from the indigenous Indian-American and Inuit dog populations, and have only marginally been mixed with European dogs in modern time.”
Savolainen, an associate professor at KTH-Royal Institute of Technology in Sweden, explained the determination after tracing the origin of mitochondrial DNA lineages for several dog breeds suspected to be pre-Columbian, meaning before Europeans settled in the Americas. Dogs inherit their mitochondrial DNA from their mothers.
“There was a single origin of the domestic dog somewhere in Eurasia,” Savolainen explained. “The exact place is still debated, but our previous studies strongly indicate the southern part of East Asia, basically southern China.”
The earliest archaeological evidence for dogs in the Americas dates to around 10,000 years ago, long before the dawn of transoceanic travel in the 15th century that saw the arrival of Columbus and other Europeans.
Most U.S. dogs today, however, have European origins. Golden retrievers, poodles and many more breeds fall into this category.
Inuit sled dogs, the Eskimo dog and the Greenland dog, though, show no European heritage in their genes. Like Native Americans, they were in the United States and nearby areas long before Europeans arrived.
“Nobody knows exactly what happened,” Savolainen said. “Most probably migrated together with the humans that entered America from Asia via the Bering Strait. These humans became today’s Indians and Inuits.”
“Our data shows dogs came in several migrations, at least one with the Indian-American ancestors and at least one with the Inuit ancestors,” he continued.
The result for Alaskan Malamutes was ambiguous, but these dogs appear to come from slightly different stock originating in Siberia, Japan, China and Indonesia. The Alaskan husky and the American Eskimo dog have a known origin from Siberian spitzes and European dogs.
The dogs with the most pre-Columbian Mexican heritage, according to the study, are the Chihuahua and Xolo (Mexican hairless dog).
The researchers additionally determined that a group of free-ranging dogs based in South Carolina and Georgia — known as Carolina Dogs — likely have an ancient Asian origin.
Carolina Dogs might have once been associated with a Native American tribe, the canine’s relatives turning feral once their humans disappeared.
“The reason might be that the human population keeping these dogs was wiped out when Europeans came,” Savolainen said.
Prior research by Sarah Brown of UC Davis and colleagues is consistent with the latest findings about the Inuit sled dog, Eskimo dog and Greenland dog. Brown and her team found “ancient DNA evidence for genetic continuity in arctic dogs.”
Scientists hope to use such DNA studies and other research on dogs to learn more about past human migrations. From at least 10,000 years onward, wherever migrating humans went, dogs often came too.
Veterinarians make sure D.C. working dogs are in shape
Veterinarians at Fort Belvoir in Virginia have kept a keen eye on working dogs — including those that watch over airports, the White House, the Capitol and other locations — for two decades. Routine preventive care as well as treatment for health problems are some of the issues addressed by veterinarian Nancy Vincent-Johnson and her colleagues at the clinic.
By Lori Aratani, for the Washington Post
The giveaway?
For more than 20 years, the squat, red brick building at Fort Belvoir is where the D.C. region’s law enforcement dogs — the ones who patrol airports, the Capitol, the White House and other high-profile locations — have been taken for care.
The region is home to one of the biggest concentrations of working dogs in the country, officials say. Canines from the Secret Service, the Transportation Security Administration, Amtrak and the U.S. Capitol Police come here for their yearly checkups. The dogs are a variety of breeds — German shepherds, Labrador retrievers, Belgian Malinois, even beagles.
“I have nothing but good things to say,’’ said Sgt. Kevin Murphy, who heads the Metropolitan Washington Airports Authority’s K-9 Unit at Dulles International Airport. “They help keep our dogs healthy.”
During the swelter of Washington’s summer, clinic workers have traveled to Dulles to conduct special sessions on spotting heatstroke and exhaustion. During the winter, handlers may receive training on spotting frostbite and hypothermia.
Belvoir’s veterinarians, a mix of civilian and military personnel, understand the special needs of their patients. These working dogs may suffer from ailments not necessarily seen in their civilian counterparts. Sometimes it’s back trouble from all their leaping into trucks and cargo hatches. Their joints can suffer strain from the same jumping. Hip dysplasia — a condition caused by improperly formed hip joints — is another common ailment.
And like the jobs held by people, the dogs’ work can be stressful, with long hours and large crowds, said veterinarian Nancy Vincent-Johnson, a 21-year Army veteran who retired and rejoined the clinic as a civilian.
Take Igor, a 9-year-old German shepherd who works for the Capitol Police. Vincent-Johnson said she had squeezed Igor, whose specialty is explosives detection, in between appointments because he has been having intestinal issues. His weight is down, and his handler says Igor — Iggy to his intimates — is just not himself.
Vincent-Johnson strokes Igor’s rich black and brown coat as she examines him, feeling the area around his rib cage and gently lifting his impressively large paws. Igor stands patiently as she moves her stethoscope along his midsection and his handler summarizes the shepherd’s symptoms.
“Maybe the food he’s on is too rich,” Vincent-Johnson theorizes. She consults Igor’s chart and notes that blood work done during his previous visit indicated a Vitamin B12 deficiency, which can lead to a type of anemia that brings on weakness and fatigue.
The poking and prodding complete, Igor settles on the floor and lets out a deep sigh.
The doctor prescribes special food for dogs with intestinal issues and a series of shots to help with the B12 deficiency.
There is now good news: Igor has put on weight — six pounds since his last visit — so the hope is that whatever is ailing him will soon be cured.
Igor’s handler leaves the office with a large bag of dog food and several bottles of medicine. Igor gets a doggie treat as a reward.
One room away, the doctor’s next patient waits with his handler, Inspector Alexandra Hassler. Upton is a TSA dog specializing in passenger screening and experienced in sniffing out explosives.
The 4-year-old black Labrador is here for the first of two physicals he’ll have this year. As part of that, Vincent-Johnson will run him through a full exam, testing his peripheral vision by waving her hands at the side of his head, eyeing his gait as he walks down the sidewalk and drawing blood for a full screening.
“His ears look good,” she says. Upton is an enthusiastic patient, eager to sniff and show approval by licking the doctor’s arm. His friskiness belies his status as one of the oldest of the TSA dogs working at Dulles. He’s also observant: Only a few minutes into the exam, he’s figured out that on the shelf that holds the jars of tongue depressors and cotton balls is one that holds crunchy treats. He can’t take his eyes off the shelf.
Vincent-Johnson says Upton is healthy. The one exception: his left back teeth. “He may need some dental work,” Vincent-Johnson tells Hassler.
Finally, Upton’s enthusiasm is rewarded. A treat flies through the air and disappears into his mouth.
So Cal Vet Hospital reaches out to Angel Fund for client
Krissy Simmel and her Dalmatian Sundaey do everything together. There was magic in their relationship from the moment they first saw each other. “We’re a match made in heaven,” Krissy says. “Sundaey is beautiful. She was born without any hearing . .. and people cross streets to tell me how special she is.”
So it was a traumatic moment when Sundaey suffered an injury on their daily two-hour walk and run in June, 2012. “She had a sports injury,” Krissy says. “I can’t really tell you what happened. She jumps a lot. She jumps five feet into trees after squirrels. She jumps into fountains. She has such a beautiful spirit. So I guess she sort of sprained her wrist or something. There was a lot of swelling and she was having a hard time walking.”
Krissy took Sundaey to Southern California Veterinary Hospital in Woodland Hills, an institution that she had found to be caring and understanding in the past. “The doctors and their staff are a special group of people,” she says. But she had recently lost her job as a restaurant hostess and was flat broke. “I don’t think I had any money in my wallet that day.”
Dr. Mark C. Rigoni examined Sundaey. “They had to take blood because they didn’t know exactly what was going on with her,” Krissy recalls. To help pay for the cost of the visit, Dr. Rigoni suggested applying to Angel Fund. The hospital also contributed and Krissy paid a small portion of the bill later.
“I really, really appreciated it,” Krissy says. “I was very surprised when they offered that to me. But the fact that they saw me at all – and they knew that I had no money – was such a blessing. And I felt like that fund was so gracious.
“Dr Rigoni and Dr. [George] Cuellar are wonderful human beings. They are always exceptional with Sundaey and with me. I was having such a difficult time that day and they were amazing.”
Within about three days, Sundaey had recovered. And she and Krissy, who lives in Santa Monica, are now enjoying their lives together as they always have. Krissy works in childcare, eldercare, real estate and as a part-time preschool teacher – with Sundaey usually at her side.
Banfield survey leads to suggestions for improving pet longevity
Banfield Pet Hospital’s State of Pet Health Report for 2013 finds that life expectancy for dogs increased by 4% since 2002 while that of cats increased by 10%. Veterinarian Jeffrey Klausner, Banfield’s chief medical officer, cautioned that a downward trend in veterinary appointments could reverse health gains for pets. Dr. Klausner suggests several steps owners in any locale can take to improve the chances their pet will live a long, healthy life, including having twice-yearly veterinary exams, spaying/neutering and keeping cats indoors. ChicagoNow.com/Steve Dale’s Pet World blog (6/13)
here’s no U.S. Centers for Disease Control for pets. Until recently, veterinarians greatly practiced in a medical bubble, only knowing what they were seeing in their own clinics. With a database of more than 800 hospitals in 43 states, Banfield the Pet Hospital, is trying to change that. The company has been keeping tabs for several years on medical conditions and other information about pets, according to the 2013 Banfield State of Pet Health Report.
One issue Banfield researched in their survey of pets, conducted in 2012, is longevity: “We’ve known all along that cats live longer than dogs, and small dogs live longer than larger dogs,” says Dr. Jeffrey Klausner, medical director at Banfield, based in Portland, OR. “However, we never knew about how geography might impact longevity.”
Overall, our dogs are living longer. The average lifespan in 2012 was 11 years, up about four percent since 2002. Cats are also living longer, for an average of 12 years, that’s up 10 percent since 2002.
The five U.S. states where cats have the longest life expectancy:
- Montana
- Colorado
- Rhode Island
- Illinois
- Nebraska
The five states where dogs enjoy the longest lives:
- South Dakota
- Montana,
- Oregon
- New Mexico
- Colorado
Interestingly, only Montana and Colorado appear on both those lists.
According to the U.S. Census Bureau and the U.S. Centers for Disease Control and Prevention, here are the top five states with the longest life expectancies for people 1999 to 2001):
- Hawaii
- Minnesota
- North Dakota
- Connecticut
- Utah
Banfield reports that these are the five states where cats have the shortest life spans:Delaware
- Delaware
- Ohio
- Louisiana
- Kentucky
- Mississippi
Here are the five states where dogs have the shortest life expectancies:
- Mississippi
- Alabama
- Louisiana
- Delaware
- Massachusetts
Apparently, Delaware, Louisiana and Mississippi aren’t states where pets thrive, at least to their full potential.
According to U.S. Census Bureau and Centers for Disease Control data, these are the five states with the shortest life spans for people (1999-2001):
- Kentucky
- South Carolina
- Alabama
- Louisiana
- Mississippi
While surprisingly, no states correlate where people and pets enjoy the longest life spans, Louisiana and Mississippi are on the list for cats, dogs and people with the shortest life expectancies.
So should people escape some states with their pets and move to others where their animals may live longer? “No, I hope not,” says Klausner. “We don’t know the significance of the data. We do know there are some steps individual pet owners can make to increase life spans. As more people spay/neuter their pets, their life spans increase. No doubt, keeping more cats indoors also plays a role. And certainly seeing veterinarians twice a year is likely to increase life span.”
As veterinary visits decline, as they have been in recent years, Klausner is concerned that this trend of pets living longer could potentially be reversed. Or perhaps pets would even be living longer than they currently do if more of them received twice-annual preventive care exams.
According to the Banfield report, the most common diagnoses for dogs were:
- Dental tartar
- Otitis externa (ear infection)
- Overweight
- Dermatitits (skin infection)
- Fleas
In cats, the most common diagnoses included:
- Dental calculus
- Overweight
- Fleas
- Gingivitis
- Otitis externa (ear infection)
Overweight pets are an epidemic. According to the Banfield report, in the past five years, the prevalence of significant excess body weight has increased 37 percent in dogs, and 90 percent in cats. This doesn’t come without consequences, contributing greatly to the 38 percent rise in arthritis in dogs and 67 increase in cats over the past five years. Diabetes in cats and dogs has about doubled over the past five years.
“Weight gain, especially in cats, happens gradually and may be difficult for owners to know has happened,” adds Klausner. “Simply weighing the pet twice a year is important.”
The Banfield survey also tallied the most common pet names. For cats, they are:
- Kitty
- Bella
- Tiger
- Max
- Smokey
The most popular names for dogs include:
- Bella
- Max
- Buddy
- Daisy
- Coco
©Steve Dale, Tribune Media Services
Newly identified genetic defect in dogs similar to rare human illness
Researchers discovered a genetic ailment afflicting dogs that is similar to a rare defect in humans called centronuclear myopathy. It results in extreme muscle weakness that eventually leads to death before the age of 18 in humans, and research could lead to treatments for both dogs and humans. Roughly six in 100,000 human infants are born with the disorder, and researchers tapped an international network of veterinarians and identified five dogs with the same genetic defect and symptoms. Studies on two colonies of dogs have tested new treatments. “Thanks to genomic comparison, we are understanding finally that dogs and humans are sick in the same way and can be treated the same way,” said veterinarian and geneticist Laurent Tiret. “Dogs help us and we help them.” ScienceMag.org/Science Now blog (6/13)
A rare genetic disease may be going to the dogs. About six in 100,000 babies are born with centronuclear myopathy, which weakens skeletal muscles so severely that children have trouble eating and breathing and often die before age 18. Now, by discovering a very similar condition in canines, researchers have a means to diagnose the disease, unravel its molecular intricacies, and target new therapies.
The story began when Jocelyn Laporte, a geneticist at the Institute of Genetics and Molecular and Cellular Biology in Strasbourg, France, uncovered the genetic roots of an odd form of centronuclear myopathy that showed up in a Turkish family. Three children, two of them fraternal twins, were born normal. Then, at the age of 3-and-a-half, they grew progressively and rapidly ill. (Most forms of the illness do not come on so suddenly.) The twins died by the age of 9. Their younger brother recently reached the same age but is very ill. Investigators traced the problem to a mutation in a gene called BIN1, which makes a protein that helps shape the muscle so that it can respond to nerve signals that initiate muscle contraction.
To find out how mutations in this gene could lead to such dire consequences, other researchers tried to genetically engineer mice models. But deleting the BIN1 gene failed to recreate the disease in mice, so the researchers had to look elsewhere.
Enter the dogs.
Laporte’s team joined with geneticist and veterinarian Laurent Tiret, at the Alfort School of Veterinary Medicine in Paris, to tap a network of vets in the United States, United Kingdom, Canada, Australia, and France. The idea was to track down and analyze dogs that had spontaneously acquired a similar condition. Because of their longer lifespans and larger size, the canines could model how the disease progresses and might respond to new therapies. Using veterinary records and muscle biopsies, the researchers found five dogs with features that mimicked human symptoms. The animals first showed problems at the age of 6 months, collapsing after exercise due to muscle weakness, for example. Biopsies of their muscle tissue also appeared similar to those of afflicted children.
Gene sequencing confirmed that the animals bore an analogous DNA mutation to the one seen in humans, which removes a large chunk of the BIN1 gene, known as exon 11. The finding of dogs with a similar defect that developed similar symptoms was key to confirming that the BIN1 is, indeed, the culprit in the human disease, Laporte says.
The team then tackled the question of how the BIN1 mutation causes such devastation. Using genomics tools, studies in cells, and analyses of biopsies, the researchers showed that the problem hovers around the formation of balloonlike structures called T-tubules deep in the muscle fibers. They are part of a muscle structure called a triad that helps convert electrical stimuli from nerve cells into mechanical muscle motion. When the T-tubules gradually become faulty, due to mutation, the muscles cannot receive the electrical stimulus to properly contract, leading to devastating symptoms. First comes muscle pain during exercise and trouble with walking, then weakness in muscles that control eye movement, and eventually problems with breathing. Using the dogs, researchers correlated the destruction of the tubules to these kinds of symptoms, as they report this month in PLOS Genetics.
Going forward, dogs will continue to be critical to unraveling this disease, Tiret says. In addition to the Great Danes, researchers, including Laporte, have found Labrador retrievers that bear two other gene mutations that cause different forms of recessive centronuclear myopathy, one linked to chromosome 2 and the other to the X chromosome. The investigators have bred those animals into two colonies. They can be used to study the natural progression of the illnesses and also to test new treatments, such as gene therapy. In fact, those treatments are already showing promise in the dogs, improving leg strength and diaphragm function during breathing, paving the way for clinical trials in humans.
The canines get around a huge hurdle that mice, zebrafish, and other organisms present when researchers try to recapitulate human disease. Often, those smaller animals express the genetic abnormality very differently from humans, says clinical scientist and pediatric neurologist James Dowling at the University of Michigan, Ann Arbor, who studies the myopathies and their genetic causes in both children and zebrafish. “The fact that the dog model seems to really faithfully recapitulate the clinical disease is really very telling,” he says. “Something that intervenes there would have a very good chance of working in patients.”
“Thanks to genomic comparison, we are understanding finally that dogs and humans are sick in the same way and can be treated the same way,” Tiret says. “Dogs help us and we help them.”
Sibling rivalry: Even the royal dog isn’t immune
With the birth of Prince William and Duchess Kate’s baby expected next month, experts say the pair would be wise to prepare their cocker spaniel, Lupo, for the royal infant’s arrival. The ASPCA’s Victoria Wells recommends all expectant parents do the same. Wells offers several recommendations parents-to-be can implement before a baby arrives, but in the end, owners must follow their intuition and re-home a pet they truly believe to be unsafe around children. NBC News (6/25)
Preparing a “canine kid” for a baby’s arrival might seem a little silly to some people, but it’s serious business according to vets and animal behaviorists. Expectant parents who don’t help their dog adjust before the new bundle appears may run into trouble down the road, when their furry friend acts out and vies for adult attention.
And the most famous royal pup in the world is no exception.
Experts say Duchess Kate, due to have her first child mid-July, should take precautionary measures now to ensure that her little Cocker Spaniel, Lupo, who the couple adopted last winter, and has already made Tatler’s 50 most fascinating “people” list, is all primed for the newest member of the royal family.
Victoria Wells, senior manager of behavior and training at the ASPCA adoption center in New York City, says she sometimes sees pregnant moms bring dogs to shelters before there’s even been a problem because they’re so anxious about their pooch getting along with their newborn.
She firmly believes that parents can take pro-active steps before a baby comes home to ensure that their “fur kid” is ready for the big change— and to calm their own prenatal nerves about everyone coexisting. She advises the Duchess of Cambridge and all other expectant moms this summer: Make sure your four-legged friend knows some basic commands, like “stay’” and “leave it,” so Fido doesn’t jump on the baby and listens when called.
“Go to dog training classes or hire a trainer,” says Wells. She also suggests teaching dogs impulse control before there’s an infant in the house.
Marc Siebert, owner and medical director of The Heart of Chelsea Animal Practice in downtown Manhattan, has seen many couples in his more than 20 years of practice balance new baby and beloved pet— and he breaks it down in canine terms for new parents.
“Most dogs will accept a new baby as part of their ‘pack’ readily,” he explains. But sometimes the dog will “see the new baby more as prey,” which is when you have problems.
So how do you convince your “canine kid” that the baby is part of the pack, royal or otherwise? Let the dog get used to the nursery and the smell of an infant before you walk in that door with the car seat, Siebert says. Encouraging your puppy to explore the new room and smell those blankets and onesies really does help a dog get acquainted with a new baby before the official introduction.
For first time mom Aubrey Bartolo, 29, of Greenwich, Conn., ensuring a smooth transition between her 7-year-old Yorkie, Rufuth, and baby girl Bartolo, born two weeks ago, was a top priority.
“We had our doula bring a blanket and a little hat home each night from the hospital,” Bartolo said, “And she’d wrap [Rufuth] up in the clothes so he was used to her smell when we came home a few days later.”
Bartolo also says she’s been reserving special, one-on-one time in their bed, every night cuddling with her “first kid”— no babies allowed.
Victoria Wells tells parents they can even buy an infant doll and use baby products on it, as well as “rocking it” to sleep in a glider to prepare the dog for what life will be like with a “sibling.”
“The key to all of this is positive reinforcement,” says Wells. “Whenever you’re interacting with the baby or the doll, before the real baby arrives, try to make a positive association for the dog and give him treats.”
Which shouldn’t be a problem at the palace, as the pregnant princess regularly receives treats for her pup from her loyal fans.
In the final analysis, though, it’s crucial to trust your gut, no matter how hard it might be to admit that your baby and pet are incompatible.
Unfortunately, for Stephanie Klein, 37, a blogger and Jericho, New York, mom of 6-year-old twins Lucas and Abigail, obedience classes and behavior therapy didn’t do the trick for her toy fox terrier, Linus. The dog had nipped various people before the twins’ arrival. And despite all the professional help she sought and progress he was making, Klein ultimately made the heartbreaking decision that it was too risky to have the dog around her babies.
Linus now lives happily as an “only child” with Klein’s sister in Florida.
Study: Lymphoma similar in humans and dogs
A study comparing canine and human B-cell lymphoma found molecular similarities between the cancers, allowing researchers to better understand the origins of the disease in both species. Researchers are optimistic that studies and clinical trials in dogs will yield treatment avenues for humans, too. “Dogs are good models to study, because it will also be possible to study shared risk factors, in the environment, for example, that might predispose both humans and dogs to get lymphoma. Our knowledge helps dogs and humans with lymphoma,” said study author and physician Kristy Richards. ScienceDaily (6/25)
June 25, 2013 — Humans and their pet dogs are close, so close that they both develop a type of cancer called diffuse large B-cell lymphoma. In humans it’s the most common lymphoma subtype while in dogs, it’s one of the most common cancers in veterinary oncology.
The study was published June 19, 2013 online in the journal Cancer Research.
Kristy Richards, MD, PhD, corresponding author, said, “Comparing the molecular similarities of lymphomas across species has allowed us to see what parts of lymphoma development and growth are evolutionarily conserved. This teaches us more about what components of human lymphoma biology are most fundamental and critical. The canine lymphoma work is now informing research on human lymphomas.” Dr. Richards is an assistant professor of medicine and a member of UNC Lineberger Comprehensive Cancer Center.
“Pet dogs get cancer the same way humans do: at similar rates, and for unknown reasons. Like humans, dogs’ tumors are spontaneously occurring, rather than genetically created as they are in mice, so canine tumors may more accurately mimic the situation in human cancer patients. Dogs are good models to study, because it will also be possible to study shared risk factors, in the environment, for example, that might predispose both humans and dogs to get lymphoma. Our knowledge helps dogs and humans with lymphoma.
“Veterinarians treating dogs for lymphoma can offer clinical trials to their owners. Clinical trials in dogs are similar to those done in humans, with safety protections in place to minimize harm.
“What we have learned in our study could facilitate faster, more efficient new drug development, allowing new therapies to get to cancer patients faster and with a higher likelihood of success.”
Molecular analyses of canine and human tumors were completed at NCSU and at UNC Lineberger. The team used gene expression profiling and found that canine B-cell lymphoma expression profiles were similar in many ways to human B-cell lymphoma, thus paving the way for future studies, including therapeutic clinical trials in dogs and humans.
Senior study author is Dr. Steven Suter, associate professor of medical oncology at the NCSU College of Veterinary Medicine. Other authors from NCSU are Alison Motsinger-Reif, Hsiao-wei Chin, Dahlia Nielsen, Rachael Thomas, Chris Smith, Matthew Breen, and Luke Borst. Sandeep Dave from Duke University was an author and other authors from UNC are Yuri Fedoriw, Cheng Fan, George Small and Charles Perou.
The work was supported by a developmental grant from the University Cancer Research Fund.
Service dog helps young man with no limbs succeed
Brandon Scott was born without most of his four limbs due to a rare disease, but with the help of his service dog, Rona, he recently graduated from college and is planning a career in sports media or public relations. Rona was trained by Canine Companions for Independence and has been by Scott’s side since he applied for a dog as a sixth-grader. WISH-TV (Indianapolis) (6/27)
Updated: Thursday, 27 Jun 2013, 1:42 PM EDT
Published : Thursday, 27 Jun 2013, 12:28 PM EDT
INDIANAPOLIS (WISH) – Indianapolis resident Brandon Scott has a rare disease, but motivation and a K-9 friend helped him beat the odds.
Brandon was born missing most of his four limbs, Rona the dog acts as his hands. She carries things and picks things up for him.
He applied through Canine Companions for Independence in the sixth grade, so he could get used to working with helper.
When he left for Ball State, his parents were relieved that he had such a reliable partner by his side.
Rona gave him the ability to feel independent and made the transition to college much easier.
Now that Brandon has graduated, he says he wants to be on a sports talk radio show or work with public relations for an Indycar team.
He is even training for the 2016 Paralympics in Rio de Janeiro.
Click here to learn more about Canine Companions for Independence.
Treating allergic dogs
Veterinarian Jeff Kahler explains that dogs often exhibit skin irritation in response to inhaled allergens, and owners must develop a plan with their veterinarian to get symptoms under control. Testing for most, but not all, allergens often aids in the development of a treatment plan, Dr. Kahler writes. Different therapies including desensitizing injections and anti-inflammatory medication, as well as additional testing for secondary infections, may be part of the plan, but without treatment, Dr. Kahler says, the allergies are likely to get worse. The Sacramento Bee (Calif.)/The Modesto Bee (Calif.) (6/26)
By JEFF KAHLER, D.V.M.
The Modesto Bee
Bogie licks and chews at his feet to the point that they are now red and swollen. Pauline says her dog has been treated with various antibiotics and corticosteroids, but as the dosage of cortisone pills decreases, the incessant licking increases. Pauline has been told Bogie has allergies, and I would have to agree.
Inhaled allergens in humans commonly cause eye irritation. In dogs, these types of allergies can cause itchy skin. So can contact allergies.
Allergies usually worsen with time as the response to them gets more and more intense, because the immune system is hyper-reacting to something in the environment. Over time, that response becomes more exaggerated.
The self-trauma stemming from the allergic response can exacerbate the inflammation and can lead to bacterial infections or a yeast infection.
Bogie needs to be tested for inhaled allergies specific to his geographic area – California’s Central Valley. This can be done through blood or skin testing. Unfortunately, it is not possible to test for every possible allergen, so a definitive diagnosis may still elude us even with the testing. This, however, is not common.
He needs cultures for bacteria and skin swabs for microscopic examination before a treatment plan can be formulated. Once the results are in from the cultures, treatment can start. I would also start anti-inflammatory treatment to try and bring Bogie some much-needed relief. The medications used for these therapies will be determined by his veterinarian.
When the allergy testing results are in, the next step is to determine if allergy injections are necessary. This therapy can usually be done at home and can have excellent results in desensitizing Bogie to whatever is causing the irritation. Not all patients respond well to desensitization, and these patients will likely have to be medicated when the symptoms warrant.
There are other possible allergic conditions that might be causing Bogie’s condition. He may need to have a diet assessment, for example, to determine if a diet allergy is suspected.
Obviously, cases like Bogie’s are complex and there is no single therapy. One thing is certain: Bogie is miserable and needs to visit his veterinarian for a treatment that results in relief.
(Jeff Kahler is a veterinarian in Modesto, Calif. Questions can be submitted to Your Pet in care of LifeStyles, The Modesto Bee, P.O. Box 5256, Modesto CA 95352.)